Protein Details: KCa5.1 (Calcium-activated channel; subfamily U; member 1)
Protein ID
ICDB_Pro_0053
Protein Name
KCa5.1 (Calcium-activated channel; subfamily U; member 1)
Gene Name
KCNU1; KCNMA3; SLO3; QtsA-16614
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Length
1149 amino acids
AlphaFoldDB
AF-A5LFX5-F1-model_v4.pdb
Function
Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1; it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges; such as those experienced after mixing with seminal fluid and entry into the vagina (By similarity)
Sequence
MFQTKLRNESWEDLQKMSCTTEIQVAFILSSFMTFISGLIILLIFRLIWRTVKKWQIIKGTGIILELFTSGSIRRNHVRSLHFHGRFRDRIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKTIPVDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPRILQILRAIKTSNSVKFSKLLSIVLSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFDSVYLVMATTSTVGFGDVVAKTSLGRTFIIFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRRKSGEINTEIVFLGESPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWDWDAGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVEQNRKVTPKQTWQKHFLNSMKNNILTQRLSDDFAGMSFPEVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPAQIRIHKNTLGFFIAETPKEVKRALFYCSVCHDDVFIPELITNCGCKSRSRQHVTVPAVKIVKKCMKGLSSHMAGQDSPPRVHASPSRISDFTTRTFPHDVEQDSDQLDSSGMFHWCKPISLDKVTLKRSRKLKHKFRNHIVACVFGDAQSALIGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLRNFPQIYILPGCALYSGDLHAANIEQCSMCVVLSPPSKPSSSQTLVDAEAILATLTIGSLQIDSSSDSSPSVSEETASCTNGHNEKSNCRKVPILIELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTVFSGSFLDSLLATSFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTTLLSGRNRCKMGLLSLHQTILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSSQKSYEIIKEASQTTETHSDTNFPPTIYSVDETSYSPVYSYPSRTNSVYSANQTARNQIRTNSSITSQKPLGDNAKKNGKKISDEISDEDPFAYSEPL
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Testis-specific.